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New Delivery for Prefilled Syringe Packaging - Ampoule Filling Production Line – IVEN

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New Delivery for Prefilled Syringe Packaging - Ampoule Filling Production Line – IVEN Detail:


The Ampoule filling production line includes vertical ultrasonic washing machine, RSM sterilizing drying machine and AGF filling and sealing machine. It is divided into washing zone, sterilizing zone, filling and sealing zone. This compact line can work together as well as independently. Compared with other manufacturers, our equipment has unique features, including overall dimension smaller, higher automation & stability, lower fault rate and maintenance cost, and etc.

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For glass ampoule production.


Production Procedures:

Step 1

Ultrasonic washing
It adopts washing technology of 2 water and 2 air on the outer wall and 3 water and 4 air on the inner wall.
6 groups of spraying needles have track washing, spray needles adopts full 316L stainless steel. Servo control system+ Guide sleeve and guide board give accurate position to the spray needle, effectively avoid needle damage caused by mismatch.
WFI and compressed air is intermittent, reduce the consumption.

Standard washing process:
1.Bottle spraying
2.Ultrasonic pre-washing
3.Recycled water: inside washing, outside washing
4.Compressed air: inside blowing
5.Recycled water: inside washing, outside washing
6.Compressed air: inside blowing
7.WFI: inside washing
8.Compressed air: inside blowing, outside blowing
9.Compressed air: inside blowing, outside blowing


Step 2

Sterilizing& Drying
The washed bottles enter into sterilizing &drying machine slowly uniformly through mesh belt. Pass through preheating zone, high temperature sterilizing zone, cooling zone gradually.
The moisture exhausting fan discharge the bottle vapor to outdoor, in high temperature zone, the bottles are sterilized about 5 minutes under 300-320℃. The cooling zone cools the sterilized vials, and finally reach to technological requirement.
The whole drying and sterilizing process is operated under real time monitoring.


Step 3

Filling& Sealing
This machine adopts a transmission system of step-by-step with balcony structure.
The machine automatically finishes the whole production process:
Auger conveying—Front nitrogen charging (optional)—Solution filling—Rear nitrogen charging (optional)— Preheating—Sealing—Counting—Finished products outputting.


Ampoule Filling Production Line Advantages

1. The compact line realizes single linkage, continuous operation from washing, sterilizing,filling and sealing. The whole production process realizes cleaning operation; protects products from contamination, meets the GMP production standard.
2. This line adopts water and compressed air cross pressure jet wash and ultrasonic wash at inverted state. The cleaning effect is very good.
3. The ultra filtration technology is applied at the washing machine’s filter. The clean and sterile washing water and compressed air is obtained through terminal filter, which can improve the clarity of the washed bottle.
4. Bottle in feed auger and star wheel meet, the auger space is small. Ampoule can walk straight. Ampoule can transfer more stable and can hardly broken.
5. The stainless manipulators are one side fix. The location is more accuracy. The manipulators are wear proof. When changing of pitch the manipulators no need stretch out and turn. The turning bearing wont contaminating the cleaning water.
6. The ampoule are sterilized by the hot air laminar flow sterilization principle. The heat distribution is more even. The ampoule are under the HDC high temperature sterilization condition, which meets the standard of GMP.
7. This equipment adopts negative pressure sealing principle to seal the high efficiency filter which are used for purify the tunnel. The filter is easy to install which can ensure the one hundred purification condition.
8. The equipment adopts hinge type seat heat and horizontal hot air fan structure. The maintenance of the equipment is more convenient and laborsaving.
9. This equipment adopts chain conveying belt with flank. The conveying belt won’t be off track, anti-creeper, no bottle falling.
10. The equipment adopts advance technology such as mufti-needle filling, front and rear nitrogen charging and wire drawing sealing, which can meet the standard of different type of products.
11. The fill-seal machine adopts balcony structure. The star wheel in feed and convey bottles continuously, the running of the equipment is stable and less bottle breakage.
12. This equipment is universal. It can’t be used to 1-20ml ampoule. Changing parts are convenient. In the meantime, the equipment can be used as vial washing, filling and capping compact line by changing some mould and out feed wheel.

Machine Configuration


Tech Parameters

Applicable specifications 1-20ml B type ampoules which meets the standard of GB2637.
Maximum capacity 7,000-10,000pcs/h
WFI consumption 0.2-0.3Mpa 1.0 m3/h
Compressed air consumption 0.4Mpa 50 m3/h
Electric capacity CLQ114Vertical ultrasonic washing machine:15.7KW
RSM620/60 Sterilizing and drying machine 46KW, heating power: 38KW
AGF12 Ampoule filling and sealing machine 2.6KW
Dimensions CLQ114Vertical ultrasonic washing machine:2500×2500×1300mm
RSM620/60 Sterilizing and drying machine:4280×1650×2400mm
AGF12 Ampoule filling and sealing machine:3700×1700×1380 mm
Weight CLQ114Vertical ultrasonic washing machine:2600 Kg
RSM620/60 Sterilizing and drying machine:4200 Kg
AGF12 Ampoule filling and sealing machine:2600 Kg

*** Note: As products are constantly updated, please contact us for latest specifications. ***

Product detail pictures:

New Delivery for Prefilled Syringe Packaging - Ampoule Filling Production Line – IVEN detail pictures

New Delivery for Prefilled Syringe Packaging - Ampoule Filling Production Line – IVEN detail pictures

New Delivery for Prefilled Syringe Packaging - Ampoule Filling Production Line – IVEN detail pictures

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We usually keep on with the principle "Quality To start with, Prestige Supreme". We've been fully committed to offering our purchasers with competitively priced excellent solutions, prompt delivery and skilled support for New Delivery for Prefilled Syringe Packaging - Ampoule Filling Production Line – IVEN , The product will supply to all over the world, such as: Malaysia, Qatar, Hongkong, You can do one-stop shopping here. And customized orders are acceptable. Real business is to get win-win situation, if possible, we would like to provide more support for customers. Welcome all nice buyers communicate details of products and ideas with us!!
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    5 Stars By Mamie from United States - 2017.08.18 18:38
    Product variety is complete, good quality and inexpensive, the delivery is fast and transport is security, very good, we are happy to cooperate with a reputable company!
    5 Stars By Kimberley from Norway - 2017.01.11 17:15
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